Murni Mahmud, a researcher in the field of Human Computer Interaction (HCI), is interested in research in the areas of interaction design evaluation methods, usability and accessibility of website user interfaces, usability and accessibility of information and technology tools/software for elderly and people with special needs. While enriching her knowledge in HCI, she is interested in research related to Information Systems, the usage of communication and interaction tools.

She is also exploring these research areas: Electronic Government and Mobile Government, Virtual Reality, Software Engineering, Development and Brain Inspire Computing and learning HCI in Malaysian context. She has completed several research projects, which include Evaluation of Islamic Website, Museum and Virtual Reality.
She develop an interest in HCI when she worked with users and computers interfaces during her first job at Exxon-Mobil, Malaysia. Currently, Murni has four research students under her supervision. She taught courses such as Human Computer Interaction, Research Methodology, System Analysis and Design, Information Retrieval Technology, Project Management in Information Technology, Management Information Systems and Database Design and Management. She also supervises Final Year Project I and II and Practical Training/Industrial Attachment.

She is a member of MyHCI-UX, MyAIS, PECAMP, Human Factor and Ergonomic Malaysia (HFEM), Association for Computing Machinery (ACM), (professional membership since April 2009), Association for Information Systems, (membership since May 2009) and Interaction Design Foundation.

Presently, Murni is a professor at the Department of Information Systems, Kulliyyah of Information and Communication Technology (KICT). Effective July 2023, she has been appointed as the dean of KICT.